Interaktivni kompleks receptora A aktiviranog peroksisomskim proliferatorom 285 je ljudski gen.
Protein kojega kodira ovaj gen je jedarni transkripcijski koaktivator za receptor alfa aktiviran proliferatorom peroksisoma. Kodirani protein sadrži cinkov prst i helikazu koja je čini se dijelom kompleksa interakcije receptora alfa koji aktivira proliferator peroksisoma. Ovaj gen je član porodice gena DNK2/NAM7 helikaza. Za ovaj gen pronađene su alternativno prerađene varijante transkripta koje kodiraju različite izoforme.
Aminokiselinska sekvenca proteina Simboli
C: Cistein D: Asparaginska kiselina E: Glutaminska kiselina F: Fenilalanin G: Glicin H: Histidin I: Izoleucin K: Lizin L: Leucin M: Metionin N: Asparagin P: Prolin Q: Glutamin R: Arginin S: Serin T: Treonin V: Valin W: Triptofan Y: Tirozin
1020304050 MAVWEAEQLGGLQRGDLLTPPAPDGDGRTAPLGQPPGAQLYCPACLVTCH SQEAFENHCASSEHAQMVAFDQALPWEHRSPPPGLSKFELCPKPDLCEYG DACTKAHSAQELQEWVRRTQAVELRGQAAWQDGLVPYQERLLAEYQRSSS EVLVLAETLDGVRVTCNQPLMYQAQERKTQYSWTFAVHSEEPLLHVALLK QEPGADFSLVAPGLPPGRLYARGERFRVPSSTADFQVGVRVQAASFGTFE QWVVFDFGRRPVLLQKLGLQLGQGRRPGPCRNLALGHPEEMERWHTGNRH VVPGVERTAEQTALMAKYKGPALALEFNRSSVASGPISPTNYRQRMHQFL YEEEAAQQQLVAKLTLRGQVFLKTALQTPALNMLFAPPGALYAEVPVPSS LMPDTDQGFLLGRAVSTALVAPVPAPDNTVFEVRLERRASSEQALWLLLP ARCCLALGLQPEARLVLEVQFQIDPMTFRLWHQAVDTLPEEQLVVPDLPT CALPRPWSVPPLRRGNRKQELAVALIAGWGPGDGRRVPPLLIYGPFGTGK TYTLAMASLEVIRRPETKVLICTHTNSAADIYIREYFHSHVSGGHPEATP LRVMYTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTTTSQ ARELRVPVGFFSHILIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVT PRLFSVARARAAEHTLLHRLFLCYQQETHEVARQSRLVFHENYRCTDAIV SFISRHFYVAKGNPIHARGKVPPHPRHYPLMFCHVAGSPDRDMSMASWLN LAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVSHGAQVSALRQELRRRD LGQVSVGSFEILPGRQFRVVVLSTVHTCQSLLSPGALAPEFFTDARVLNT VLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPEGLSMEQ VEQGVAQRRRWPPRGTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEP GDEALSPASRDITATTAQTEAAAAPAGDAVKEDVVPGACAAGAAAAAGVE STEAEDAEADFWPWDGELNADDAILRELLDESQKVMVTVGEDGLLDTVAR PESLQQARLYENLPPAALRKLLHAEPERYRHCSFVPETFERASAIPLDDA SSGPIQVRGRLDCGMAFAGDEVLVQLLSGDKAPEGRLRGRVLGVLKRKRH ELAFVCRMDTWDPRIMVPINGSVTKIFVAELKDPSQVPIYSLRKGRLQRV GLERLTAEARHSRLFWVQIVLWRQGFYYPLGIVREVLPEASTWEQGLRIL GLEYSLRVPPSDQATITKVLQKYHTELGRVAGRREDCRAFLTFTVDPQGA CNLDDALSVRDLGPRCEVAVHITDVASFVPRDGVLDVEARRQGAAFYAPG REPVPMLPASLCQDVLSLLPGRDRLAISLFLTMEKASGQLKSLRFAPSVV QSDRQLSYEEAEEVIRQHPGAGRELPARLDSVDACVVAACYFSRLLRRHR LRSDCFYEQPDEDGTLGFRAAHIMVKEYMIQFNRLVAEFLVGSECTRTVT PLRWQPAPRSQQLKALCEKHGDRVPLSLHLGHHLHGGGGSPPDTRLHLLA SLWKQVQFAARTQDYEQMVDLVTTDDMHPFLAPAGRDLRKALERSAFGRC ARGHQQQGGHYSLQVDWYTWATSPIRRYLDVVLQRQILLALGHGGSAYSA RDIDGLCQAFSLQHALAQSYQRRARSLHLAVQLKAQPLDKLGFVVDVEAG SRCFRLLFPSNRETLPDPCPVPYGSLQLAEHPHALAGRPGLRLLWRRRVY SAQGSSPPLPLPGTVPDPHTLAVETALWKQLLELVELQRWPEAAALIQEK GEASQRRELVQVQRSHCGHFLEVARELGSGDTLQVQLGTSLQHGFLVPSP QLWTVAPGFSLCLEHVERPGDCFSGRVYRAPRDRYRDVDEYACVWEPFCA LESATGAVAENDSVTLQHLSVSWEASRTPQGQLQGAFRLEAAFLEENCAD INFSCCYLCIRLEGLPAPTASPRPGPSSLGPGLNVDPGTYTWVAHGQTQD WDQERRADRQEAPRRVHLFVHHMGMEKVPEEVLRPGTLFTVELLPKQLPD LRKEEAVRGLEEASPLVTSIALGRPVPQPLCRVIPSRFLERQTYNIPGGR HKLNPSQNVAVREALEKPFTVIQGPPGTGKTIVGLHIVFWFHKSNQEQVQ PGGPPRGEKRLGGPCILYCGPSNKSVDVLAGLLLRRMELKPLRVYSEQAE ASEFPVPRVGSRKLLRKSPREGRPNQSLRSITLHHRIRQAPNPYSSEIKA FDTRLQRGELFSREDLVWYKKVLWEARKFELDRHEVILCTCSCAASASLK ILDVRQILVDEAGMATEPETLIPLVQFPQAEKVVLLGDHKQLRPVVKNER LQNLGLDRSLFERYHEDAHMLDTQYRMHEGICAFPSVAFYKSKLKTWQGL RRPPSVLGHAGKESCPVIFGHVQGHERSLLVSTDEGNENSKANLEEVAEV VRITKQLTLGRTVEPQDIAVLTPYNAQASEISKALRREGIAGVAVSSITK SQGSEWRYVLVSTVRTCAKSDLDQRPTKSWLKKFLGFVVDPNQVNVAVTR AQEGLCLIGDHLLLRCCPLWRSLLDFCEAQQTLVPAGQVRVCRRPTMPS
Reference
Dopunska literatura
Kategorija:Geni Kategorija:Ljudski proteini Kategorija:Geni na hromosomu 20