Dinorfin A

Dinorfin A je dinorfinski, endogen i opioidni peptid koji aktivira κ-opioidni receptor. Njegova aminokiselinska sekvenca je Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys (YGGFLRRIRPKLK), tridekapeptid.

Dinorfin A1–8 je skraćeni oblik dinorfina A s aminokiselinskom sekvencom: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile (YGGFLRRI). Dynorphin A1–8 je agonist na mu-, kappa- i delta-opioidnim receptorima; it has the highest binding affinity for the kappa-opioid receptor. Structures of dynorphin A bound to the κ-opioid receptor have been reported.

Reference

Kategorija:Neuropeptidi Kategorija:Opioidi