Esta é a lista de finais em duplas mistas do US Open.
O período de 1892–1967 refere-se à era amadora, sob o nome de U.S. National Championships. O US Open, a partir de 1968, refere-se à era profissional ou aberta.
Por ano Era aberta {| class="wikitable sortable nowrap" style=font-size:90% |- ! Ano ! width=200 | Campeões ! width=200 | Vice-campeões ! width=100 | Resultado ! width=5 | Piso |- | 2025 || Sara Errani Andrea Vavassori || Iga Swiatek Casper Ruud || 6-3, 5–7, [10-6] || align="center" | |- | 2024 || Sara Errani Andrea Vavassori || Taylor Townsend Donald Young || 7–60, 7–5 || align=center | |- | 2023 || Anna Danilina Harri Heliövaara || Jessica Pegula Austin Krajicek || 6–3, 6–4 || align=center | |- | 2022 || Storm Sanders John Peers || Kirsten Flipkens Édouard Roger-Vasselin || 4–6, 6–4, [10–7] || align=center | |- | 2021 || Desirae Krawczyk Joe Salisbury || Giuliana Olmos Marcelo Arévalo || 7–5, 6–2 || align=center | |- | data-sort-value="2020" colspan=5 align=center style=background:#cfcfcf | Torneio de mistas não realizado em 2020, devido à pandemia de COVID-19. |- | 2019 || Bethanie Mattek-Sands Jamie Murray || Chan Hao-ching Michael Venus || 6–2, 6–3 || align=center | |- | 2018 || Bethanie Mattek-Sands Jamie Murray || Alicja Rosolska Nikola Mektić || 2–6, 6–3, [11–9] || align=center | |- | 2017 || Martina Hingis Jamie Murray || Chan Hao-ching Michael Venus || 6–1, 4–6, [10–8] || align=center | |- | 2016 || Laura Siegemund Mate Pavić || Coco Vandeweghe Rajeev Ram || 6–4, 6–4 || align=center | |- | 2015 || Martina Hingis Leander Paes || Bethanie Mattek-Sands Sam Querrey || 6–4, 3–6, [10–7] || align=center | |- | 2014 || Sania Mirza Bruno Soares || Abigail Spears Santiago González || 6–1, 2–6, [11–9] || align=center | |- | 2013 || Andrea Hlaváčková Max Mirnyi || Abigail Spears Santiago González || 7–65, 6–3 || align=center | |- | 2012 || Ekaterina Makarova Bruno Soares || Květa Peschke Marcin Matkowski || 6–7, 6–1, [12–10] || align=center | |- | 2011 || Melanie Oudin Jack Sock || Gisela Dulko Eduardo Schwank || 7–6, 4–6, [10–8] || align=center | |- | 2010 || Liezel Huber Bob Bryan || Květa Peschke Aisam-ul-Haq Qureshi || 6–4, 6–4 || align=center | |- | 2009 || Carly Gullickson Travis Parrott || Cara Black Leander Paes || 6–2, 6–4 || align=center | |- | 2008 || Cara Black Leander Paes || Liezel Huber Jamie Murray || 7–66, 6–4 || align=center | |- | 2007 || Victoria Azarenka Max Mirnyi || Meghann Shaughnessy Leander Paes || 6–4, 7–66 || align=center | |- | 2006 || Martina Navrátilová Bob Bryan || Květa Peschke Martin Damm || 6–2, 6–3 || align=center | |- | 2005 || Daniela Hantuchová Mahesh Bhupathi || Katarina Srebotnik Nenad Zimonjić || 6–4, 6–2 || align=center | |- | 2004 || Vera Zvonareva Bob Bryan || Alicia Molik Todd Woodbridge || 6–3, 6–4 || align=center | |- | 2003 || Katarina Srebotnik Bob Bryan || Lina Krasnoroutskaya Daniel Nestor || 5–7, 7–5, 7–65 || align=center | |- | 2002 || Lisa Raymond Mike Bryan || Katarina Srebotnik Bob Bryan || 7–6, 7–6 || align=center | |- | 2001 || Rennae Stubbs Todd Woodbridge || Lisa Raymond Leander Paes || 6–4, 5–7, 7–6 || align=center | |- | 2000 || Arantxa Sánchez Vicario Jared Palmer || Anna Kournikova Max Mirnyi || 6–4, 6–3 || align=center | |- | 1999 || Ai Sugiyama Mahesh Bhupathi || Kimberly Po Donald Johnson || 6–4, 6–4 || align=center | |- | 1998 || Serena Williams Max Mirnyi || Lisa Raymond Patrick Galbraith || 6–2, 6–2 || align=center | |- | 1997 || Manon Bollegraf Rick Leach || Mercedes Paz Pablo Albano || 3–6, 7–5, 7–63 || align=center | |- | 1996 || Lisa Raymond Patrick Galbraith || Manon Bollegraf Rick Leach || 7–6, 7–6 || align=center | |- | 1995 || Meredith McGrath Matt Lucena || Gigi Fernández Cyril Suk || 6–4, 6–4 || align=center | |- | 1994 || Elna Reinach Patrick Galbraith || Jana Novotná Todd Woodbridge || 6–2, 6–4 || align=center | |- | 1993 || Helena Suková Todd Woodbridge || Martina Navrátilová Mark Woodforde || 6–3, 7–6 || align=center | |- | 1992 || Nicole Provis Mark Woodforde || Helena Suková Tom Nijssen || 4–6, 6–3, 6–3 || align=center | |- | 1991 || Manon Bollegraf Tom Nijssen || Arantxa Sánchez Vicario Emilio Sánchez Vicario || 6–2, 7–6 || align=center | |- | 1990 || Elizabeth Sayers Smylie Todd Woodbridge || Natalia Zvereva Jim Pugh || 6–4, 6–2 || align=center | |- | 1989 || Robin White Shelby Cannon || Meredith McGrath Rick Leach || 3–6, 6–2, 7–5 || align=center | |- | 1988 || Jana Novotná Jim Pugh || Elizabeth Sayers Smylie Patrick McEnroe || 7–5, 6–3 || align=center | |- | 1987 || Martina Navrátilová Emilio Sánchez || Betsy Nagelsen Paul Annacone || 6–4, 6–7, 7–6 || align=center | |- | 1986 || Raffaella Reggi Sergio Casal || Martina Navrátilová Peter Fleming || 6–4, 6–4 || align=center | |- | 1985 || Martina Navrátilová Heinz Günthardt || Elizabeth Sayers Smylie John Fitzgerald || 6–3 6–4 || align=center | |- | 1984 || Manuela Maleeva Tom Gullikson || Elizabeth Sayers Smylie John Fitzgerald || 2–6, 7–5, 6–4 || align=center | |- | 1983 || Elizabeth Sayers Smylie John Fitzgerald || Barbara Potter Ferdi Taygan || 3–6, 6–3, 6–4 || align=center | |- | 1982 || Anne Smith Kevin Curren || Barbara Potter Ferdi Taygan || 6–7, 7–6, 7–6 || align=center | |- | 1981 || Anne Smith Kevin Curren || JoAnne Russell Steve Denton || 6–4, 7–6 || align=center | |- | 1980 || Wendy Turnbull Marty Riessen || Betty Stöve Frew McMillan || 7–5, 6–2 || align=center | |- | 1979 || Greer Stevens Bob Hewitt || Betty Stöve Frew McMillan || 6–3, 7–5 || align=center | |- | 1978 || Betty Stöve Frew McMillan || Billie Jean King Ray Ruffels || 6–3, 7–6 || align=center | |- | 1977 || Betty Stöve Frew McMillan || Billie Jean King Vitas Gerulaitis || 6–2, 3–6, 6–3 || align=center | |- | 1976 || Billie Jean King Phil Dent || Betty Stöve Frew McMillan || 3–6, 6–2, 7–5 || align=center | |- | 1975 || Rosie Casals Dick Stockton || Billie Jean King Fred Stolle || 6–3, 7–6 || align=center | |- | 1974 || Pam Teeguarden Geoff Masters || Chris Evert Jimmy Connors || 6–1, 7–6 || align=center | |- | 1973 || Billie Jean King Owen Davidson || Margaret Court Marty Riessen || 6–3, 3–6, 7–6 || align=center | |- | 1972 || Margaret Court Marty Riessen || Rosie Casals Ilie Năstase || 6–3, 7–5 || align=center | |- | 1971 || Billie Jean King Owen Davidson || Betty Stöve Bob Maud || 6–3, 7–5 || align=center | |- | 1970 || Margaret Court Marty Riessen || Judy Tegart Dalton Frew McMillan || 6–4, 6–4 || align=center | |- | 1969 || Margaret Court Marty Riessen || Françoise Durr Dennis Ralston || 6–4, 7–5 || align=center | |- | 1968 || Mary-Ann Eisel Peter Curtis || Tory Fretz Gerry Perry || 6–4, 7–5 || align=center |
Era amadora Ano Campeões Vice-campeões Resultado Piso 1967 Billie Jean King Owen Davidson || Rosie Casals Stan Smith || 6–3, 6–2 || align=center | |- | 1966 || Donna Floyd Fales Owen Davidson Carol Aucamp Ed Rubinoff 6–1, 6–3 1965 Margaret Court Fred Stolle || Judy Tegart Frank Froehling || 6–2, 6–2 || align=center | |- | 1964 || Margaret Court John Newcombe Judy Tegart Ed Rubinoff 10–6, 4–6, 6–3 1963 Margaret Court Ken Fletcher || Judy Tegart Ed Rubinoff || 3–6, 8–6, 6–2 || align=center | |- | 1962 || Margaret Court Fred Stolle Lesley Turner Bowrey Frank Froehling 7–5, 6–2 1961 Margaret Court Bob Mark || Darlene Hard Dennis Ralston || default || align=center | |- | 1960 || Margaret Osborne duPont Neale Fraser Maria Esther Bueno Antonio Palafox 6–3, 6–2 1959 Margaret Osborne duPont Neale Fraser || Janet Hopps Bob Mark || 7–5, 13–15, 6–2 || align=center | |- | 1958 || Margaret Osborne duPont Neale Fraser Maria Esther Bueno Alex Olmedo 6–3, 3–6, 9–7 1957 Althea Gibson Kurt Nielsen || Darlene Hard Bob Howe || 6–3, 9–7 || align=center | |- | 1956 || Margaret Osborne duPont Ken Rosewall Darlene Hard Lew Hoad 9–7, 6–1 1955 Doris Hart Vic Seixas || Shirley Fry Lew Hoad || 9–7, 6–1 || align=center | |- | 1954 || Doris Hart Vic Seixas Margaret Osborne duPont Ken Rosewall 4–6, 6–1, 6–1 1953 Doris Hart Vic Seixas || Julia Ann Sampson Rex Hartwig || 6–2, 4–6, 6–4 || align=center | |- | 1952 || Doris Hart Frank Sedgman Thelma Long Lew Hoad 6–3, 7–5 1951 Doris Hart Frank Sedgman || Shirley Fry Mervyn Rose || 6–3, 6–2 || align=center | |- | 1950 || Margaret Osborne duPont Ken McGregor Doris Hart Frank Sedgman 6–4, 3–6, 6–3 1949 Louise Brough Clapp Eric Sturgess || Margaret Osborne duPont William F. Talbert || 4–6, 6–3, 7–5 || align=center | |- | 1948 || Louise Brough Clapp Thomas Brown Margaret Osborne duPont William F. Talbert 6–4, 6–4 1947 Louise Brough Clapp John Bromwich || Gussie Moran Pancho Segura || 6–3, 6–1 || align=center | |- | 1946 || Margaret Osborne duPont William Talbert Louise Brough Clapp Robert Kimbrell 6–3, 6–4 1945 Margaret Osborne duPont William Talbert || Doris Hart Bob Falkenberg || 6–4, 6–4 || align=center | |- | 1944 || Margaret Osborne duPont William Talbert Dorothy Bundy Donald McNeill 6–2, 6–3 1943 Margaret Osborne duPont William Talbert || Pauline Betz Pancho Segura || 10–6, 6–4 || align=center | |- | 1942 || Louise Brough Clapp Ted Schroeder Patricia Todd Alejo Russell 3–6, 6–1, 6–4 1941 Sarah Palfrey Cooke Jack Kramer || Pauline Betz Robert Riggs || 4–6, 6–4, 6–4 || align=center | |- | 1940 || Alice Marble Bobby Riggs Dorothy Bundy Cheney Jack Kramer 9–7, 6–1 1939 Alice Marble Harry Hopman || Sarah Palfrey Cooke Elwood Cooke || 9–7, 6–1 || align=center | |- | 1938 || Alice Marble Don Budge Thelma Coyne Long John Bromwich 6–1, 6–2 1937 Sarah Palfrey Cooke Don Budge || Sylvia Henrotin Yvon Petra || 6–2, 8–10, 6–0 || align=center | |- | 1936 || Alice Marble Gene Mako Sarah Palfrey Cooke Don Budge 6–3, 6–2 1935 Sarah Palfrey Cooke Enrique Maier || Kay Stammers Roderich Menzel || 6–4, 4–6, 6–3 || align=center | |- | 1934 || Helen Jacobs George Lott Elizabeth Ryan Lester Stoefen 4–6, 13–11, 6–2 1933 Elizabeth Ryan Ellsworth Vines || Sarah Palfrey Cooke George Lott || 11–9, 6–1 || align=center | |- | 1932 || Sarah Palfrey Cooke Fred Perry Helen Jacobs Ellsworth Vines 6–3, 7–5 1931 Betty Nuthall Shoemaker George Lott || Anna McCune Harper Wilmer Allison || 6–3, 6–3 || align=center | |- | 1930 || Edith Cross Wilmer Allison Marjorie Morrill Frank Shields 6–4, 6–4 1929 Betty Nuthall Shoemaker George Lott || Phyllis Covell Henry W. Austin || 6–3, 6–3 || align=center | |- | 1928 || Helen Wills Moody John Hawkes Edith Cross Edgar Moon 6–1, 6–3 1927 Eileen Bennett Whittingstall Henri Cochet || Hazel Hotchkiss Wightman Rene Lacoste || 6–2, 6–0, 6–3 || align=center | |- | 1926 || Elizabeth Ryan Jean Borotra Hazel Hotchkiss Wightman Rene Lacoste 6–4, 7–5 1925 Kathleen McKane Godfree John Hawkes || Ermintrude H. Harvey Vincent Richards || 6–2, 6–4 || align=center | |- | 1924 || Helen Wills Moody Vincent Richards Molla Bjurstedt Mallory Bill Tilden 6–8, 7–5, 6–0 1923 Molla Bjurstedt Mallory Bill Tilden || Kitty McKane Godfree John B. Hawkes || 6–3, 2–6, 10–8 || align=center | |- | 1922 || Mary Browne Bill Tilden Helen Wills Moody Howard Kinsey 6–4, 6–3 1921 Mary Browne Bill Johnston || Molla Bjurstedt Mallory Bill Tilden || 3–6, 6–4, 6–3 || align=center | |- | 1920 || Hazel Hotchkiss Wightman Wallace F. Johnson Molla Bjurstedt Mallory Craig Biddle 6–4, 6–3 1919 Marion Zinderstein Vincent Richards || Florence Ballin Bill Tilden || 2–6, 11–9, 6–2 || align=center | |- | 1918 || Hazel Hotchkiss Wightman Irving Wright Molla Bjurstedt Mallory Fred Alexander 6–2, 6–3 1917 Molla Bjurstedt Mallory Irving Wright || Florence Ballin Bill Tilden || 10–12, 6–1, 6–3 || align=center | |- | 1916 || Eleonora Sears Willis E. Davis Florence Ballin Bill Tilden 6–4, 7–5 1915 Hazel Hotchkiss Wightman Harry Johnson || Molla Bjurstedt Mallory Irving Wright || 6–0, 6–1 || align=center | |- | 1914 || Mary Browne Bill Tilden Margaretta Myers J. R. Rowland 6–1, 6–4 1913 Mary Browne Bill Tilden || Dorothy Green C. S. Rogers || 7–5, 7–5 || align=center | |-