125px|right O cromossoma 4 é um dos 23 pares de cromossomas do cariótipo humano.
Possui cerca de 186 milhões de pares de bases e representa cerca de 6% a 6,5% de todo o DNA presente na célula.
Contém entre 700 e 1110 genes.
Genes Locus Gene Descrição4q25-q27ANK2ankyrin 2, neuronalComplement Factor IComplement Factor ICRMP1Collapsin response mediator protein 1, a member of CRMP familyCXCL1chemokine (C-X-C motif) ligand 1, scyb1CXCL2 chemokine (C-X-C motif) ligand 2, scyb2CXCL3chemokine (C-X-C motif) ligand 3, scyb3CXCL4chemokine (C-X-C motif) ligand 4, Platelet factor-4, PF-4, scyb4CXCL5chemokine (C-X-C motif) ligand 5, scyb5CXCL6chemokine (C-X-C motif) ligand 6, scyb6CXCL7chemokine (C-X-C motif) ligand 7, PPBP, scyb7CXCL8chemokine (C-X-C motif) ligand 8, interleukin 8 (IL-8), scyb8CXCL9chemokine (C-X-C motif) ligand 9, scyb9CXCL10chemokine (C-X-C motif) ligand 10, scyb10CXCL11chemokine (C-X-C motif) ligand 11, scyb11CXCL13chemokine (C-X-C motif) ligand 13, scyb13DUX4Thought to be inactive but 2010 research shows a key role in FSHDEVCEllis van Creveld syndromeEVC2Ellis van Creveld syndrome 2 (limbin)Factor XIMutations cause Haemophilia CFGF2Fibroblast growth factor 2 (basic fibroblast growth factor)FGFR3fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism, bladder cancer)FGFRL1fibroblast growth factor receptor-like 1HCL2 (also called RHA or RHC)related to red hairHTT (Huntingtin)huntingtin protein (Huntington's disease)IGJlinker protein for immunoglobulin alpha and mu polypeptidesKDRKinase insert domain receptor (Vascular endothelial growth factor receptor 2)MMAAmethylmalonic aciduria (cobalamin deficiency) cblA typePHOX2Bcodes for a homeodomain transcription factorPKD2polycystic kidney disease 2 (autosomal dominant)PLK4Serine/threonine-protein kinase PLK4QDPRquinoid dihydropteridine reductaseSTATHgene with protein productSNCAsynuclein, alpha (non A4 component of amyloid precursor)UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)UNC5Cnetrin receptor UNC5CWFS1
Doenças
Algumas das doenças relacionadas com genes localizados no cromossoma 4:
Síndrome de Ellis-Van Creveld Hipocondroplasia Acondroplasia Doença de Huntington Acidemia metilmalónica Síndrome de Muenke Surdez não sindrómica Surdez não-sindrómica, autossómica dominante Síndrome de Romano-Ward Doença de Parkinson Displasia tanatofórica Displasia tanatofórica (tipo 1) Displasia tanatofórica (tipo 2) Cancro da bexiga Doença renal policística
Categoria:Genética humana